- Substance: Augmentin
- Manufacturer: Intas
- Package: 1000mg (4 capsules)
Megamentin a combined antibiotic comprising amoxycillin and clavulanic acid, with a broad spectrum bactericidal action, resistant to beta-lactamase.
Amoxicillin – is a semi-synthetic broad-spectrum antibiotic active against many gram-positive and gram-negative microorganisms.Amoxicillin collapses under deystviembeta-lactamases, and has no effect on the microorganisms which produce etoferment. Its mechanism of action is to inhibit biosintezamukopeptidov cell wall.
Clavulanic acid – a beta-laktamat structurally related penicillins, which has the ability to inactivate a wide spektrbeta-lactamase. Beta-lactamases are produced by many gram-positive bacteria igramotritsatelnymi. The action of beta-lactamases can lead krazrusheniyu some antibacterial drugs even before they vozdeystviyana pathogens. Clavulanic acid blocks the action of enzymes, bacteria vosstanavlivayachuvstvitelnost to amoxycillin. In particular, it has vysokoyaktivnostyu plasmid against beta-lactamases, which often svyazanalekarstvennaya resistance, but is less effective against hromosomnyhbeta lactamase-1 type.
The presence of clavulanic acid in the Megamentin protects amoxicillin from the destructive action of beta-lactamases and extends its spectrum of antibacterial activity to include the microorganisms normally resistant to other cephalosporins and penicillins.
Dosing of Megamentin
Before assigning the patient drug to determine sensitivity to the hair, have caused disease in a particular patient. Doses set individually depending on the severity, localization of infection and susceptibility.
Children under the age of 1 year, the drug is administered as drops. Single dose for children up to 3 months. – 0.75 mL for children from 3 months. up to a year – 1.25 ml. In severe cases, intravenous single dose for children aged 3 months. up to 12 years is 30 mg / kg body weight; preparation is administered every 6-8 hours for children up to 3 months are administered a single dose of 30 mg / kg body weight: and preterm children during the perinatal period (for 7th day neonate) – every 12 hours, and then every 8 hours treatment.. The drug should not continue for more than 14 days without a review of the clinical situation.
Side effects of Megamentin
Rarely – dyspepsia (indigestion). The severity of dyspeptic side effects may be reduced while taking the drug with food. Described isolated cases of impaired liver function, the development of hepatitis, cholestatic jaundice (jaundice associated with the stagnation of bile in zhelchevyvodyashih ways). There are few reports about the development of pseudomembranous colitis (intestinal colic, characterized by bouts of abdominal pain and the release of large amounts of mucus in the feces). Rarely -krapivnitsa, angioedema (allergic edema); very rarely – anaphylactic (allergic) shock poliformnaya erythema (infectious-allergic disease characterized by redness symmetric skin and temperature rise), cider Stevens-Johnson (disease characterized by redness and bleeding into mucous membranes of the mouth, urethra and conjunctiva / outer coat of the eye /), exfoliative dermatitis (redness of the whole body with its expressed ecdysis). Rarely -kandidoz (a fungal disease) and other types of superinfection (heavy, rapidly developing form of an infectious disease caused by resistant to malaria infections formerly in the body, but does not show itself). In some cases, the opportunity to develop phlebitis (vein inflammation) at the injection site.